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Abstract. Traumatic brain injury has been associated with increased risk of Parkinson disease and parkinsonism, and parkinsonism and Lewy body disease (LBD) can occur with chronic traumatic encephalopathy (CTE). To test whether contact sports and CTE are associated with LBD, we compared deceased contact sports athletes (n = 269) to cohorts from.
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Currently, the neuropathological diagnosis of Lewy body disease (LBD) may be stated according to several staging systems, which include the Braak Lewy body stages (Braak), the consensus criteria by McKeith and colleagues (McKeith), the modified McKeith system by Leverenz and colleagues (Leverenz), and the Unified Staging System by Beach and colleagues (Beach). All of these systems use semi.
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Received: May 23, 2018/Published online: July 9, 2018 The Author(s) 2018 ABSTRACT Dementia with Lewy bodies is one of the most common causes of dementia. It is not as common as Alzheimer's disease; the general public's awareness of the disease is poor in comparison.
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Dementia with Lewy bodies and Parkinson's disease dementia, jointly known as Lewy body dementia, are common neurodegenerative conditions. Patients with Lewy body dementia present with a wide range of cognitive, neuropsychiatric, sleep, motor, and autonomic symptoms. Presentation varies between patients and can vary over time within an individual.
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The Lewy fold is formed by residues 31-100 of α-synuclein, which arrange as nine β-strands (β1-9) in a three-layered structure (Fig. 2 ). The first two layers are corrugated, with the first.
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Guerreiro et al., 26 Oct 2018 - preprint copy - BioRxiv 3 Abstract Recent large-scale genetic studies have allowed for the first glimpse of the effects of common genetic variability in dementia with Lewy bodies (DLB), identifying risk variants with appreciable effect sizes. However, it is currently well established that a
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Dementia with Lewy bodies is one of the most common causes of dementia. It is not as common as Alzheimer's disease; the general public's awareness of the disease is poor in comparison. Its effects on caregivers and patients alike are not well known to the general population.
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Abstract. The Dementia with Lewy Bodies (DLB) Consortium has refined its recommendations about the clinical and pathologic diagnosis of DLB, updating the previous report, which has been in widespread use for the last decade. The revised DLB consensus criteria now distinguish clearly between clinical features and diagnostic biomarkers, and give.
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This work identified progressive disabling mental impairment progressing to dementia as the central feature of DLB, and identified optimal staining methods for each of these and devised a protocol for the evaluation of cortical LB frequency based on a brain sampling procedure consistent with CERAD.
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INTRODUCTION. In 1817, Parkinson described the clinical features of six cases of the disease named after him. 1 In 1980, Kosaka et al. proposed the term Lewy body disease (LBD). 2 In 1996, the first consensus guideline on dementia with Lewy bodies was published. 3 LBD is a disease concept characterized by the presence of Lewy bodies (LBs) and Lewy neurites and includes Parkinson's disease (PD.
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To date, it is far from clear whether Lewy body accumulation or ß-amyloid or tau protein enrichment play any active role in the ongoing chronic disease process itself in the affected neurons. They may also just represent well-wrapped protein garbage as a consequence of disease-affected neurons [ 3 ].
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Lewy body dementia (LBD) is a disease associated with abnormal deposits of a protein called alpha-synuclein in the brain. The deposits, called Lewy bodies, affect chemicals in the brain whose changes can lead to problems with thinking, movement, behavior, and mood. LBD is one of the most common causes of dementia, after Alzheimer's disease and vascular disease.
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Methods: Autopsy reports at the Clinical Department of Pathology in Lund from 2001-2018 were analyzed. All cases with a complete neuropathological diagnosis of LBD were selected, not distinguishing between subjects with clinical Parkinson disease dementia and dementia with Lewy bodies, on the condition of a clinical diagnosis of dementia.
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Association of Lewy Bodies With Age-Related Clinical Characteristics in Black and White Decedents. Goldstein FC, Levey A, Wharton W. A meta-analysis of Alzheimer's disease incidence and prevalence comparing African-Americans and Caucasians.. biostatistician, 2009-2021 NIA, U01AG046152, biostatistician, 2013-2018 NIA, R01AG054058.
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Lewy body dementia (LBD) and Alzheimer's disease (AD) are common forms of dementia that have different clinical profiles but are both commonly associated with attentional deficits. The aim of this study was to investigate efficiency of different attentional systems in LBD and AD and its association with brain structural abnormalities. We studied reaction time (RT) data from 45 LBD, 31 AD.
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A small randomised controlled trial comparing citalopram, a selective serotonin reuptake inhibitor, with risperidone in 14 patients with dementia with Lewy bodies did not show efficacy and found high overall burden of side-effects. More studies with antidepressants have been conducted in Parkinson's disease.
